Educational Forum with Clinical Studies Current Science and Research

February 27, 2011

FREQUENCY SPECIFIC EFFECTS OF DOPAMINE IN THE NUCLEUS ACCUMBENS

The action of dopamine was evaluated in the nucleus accumbens of acutely prepared rabbits. It was found that the effect of iontophoretically applied dopamine depended upon the frequency of stimulation of an afferent pathway; in this case the ipsilateral fimbria. Dopamine had a marked suppressive effect on field responses evoked by fimbria stimulation at 0.5 Hz, but not those responses evoked at 6.0 Hz. Dopamine was also effective in activating adenylate cyclase. Both the physiological and the biochemical effects of dopamine could be blocked by appropriate antagonists, suggesting that the phenomena observed were receptor mediated. It is suggested that dopamine serves to enhance information arriving from the hippocampal formation within the theta range by the suppression of competing non-theta activity.

Xanya Sofra Weiss

Xanya Sofra Weiss

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