Educational Forum with Clinical Studies Current Science and Research

January 25, 2011

A Low Power Digital IC Design Inside the Wireless Endoscopy Capsule. Xanya Sofra Weiss

Filed under: Xanya Sofra Weiss — Tags: — Dr. Xanya @ 11:38 pm

Xiang Xie, GuoLin Li, XinKai Chen, Lu Liu, Chun Zhang and ZhiHua Wang

This paper proposes an analog-digital mix-mode low power IC architecture inside the wireless endoscopic capsule, which assures that the capsule can implement the diagnoses of whole human digestive tract and provides real time endoscopic image monitoring. A new low complexity and low power digital IC design inside the wireless endoscopic capsule is discussed in detail. To decrease the power consumption, a novel architecture of three-stage clock management is applied for such a system. A new image compression algorithm based on Bayer image format and its corresponding hardware architecture are both presented for low power and low communication data rate application. The digital circuits were verified on FPGAs and have been implemented in 0.18μm CMOS process.

Xanya Sofra Weiss

Xanya Sofra Weiss

Microcurrent therapeutic technique for treatment of radiation toxicity. Xanya Sofra Weiss

Filed under: Xanya Sofra Weiss — Tags: — Dr. Xanya @ 11:00 pm
Arlene Lennox, Sandra Funder; 2000

The present technique provides a method of remediating the toxicities associated with radiation therapy. A conductive gel is applied to the affected bodily area. A sinusoidally pulsed biphasic DC current is then applied to the affected bodily area using at least one electrode. The electrode is manipulated using active tactile manipulation by for a predetermined time and the frequency of the sinusoidally pulsed biphasic DC current is decreased during the course of the treatment. The method also includes applying a spiked pulsed biphasic DC current to the affected bodily area using at least one electrode. This electrode is also manipulated using active tactile manipulation by for a predetermined time and the frequency of the spiked pulsed biphasic DC current is also decreased during the course of the treatment.

Xanya Sofra Weiss

Xanya Sofra Weiss

Studies of principle and method to depress the air-gap effect to the clamp-on micro-current transducer. Xanya Sofra Weiss

Filed under: Xanya Sofra Weiss — Tags: — Dr. Xanya @ 10:57 pm
Kai Zhou Pan Chen Buxin You Hao Yang Yang Li
Jiangbei Power Supply Bur. of Chongqing Electr. Power Corp., Chongqing; 2008

The amplitude-phase characteristic of the transducer and the effect of the gap to the magnetic resistance, inductance and mutual inductance of the transducer are analyzed by the equivalent model of passing through clamp-on micro-current transducer. Because of the gap, the lower limiting frequency of the transducer increase and the bandwidth turn narrow, as well as the voltage induced by the coil of the transducer is so feebleness and easy to be interfered that it is difficult to be measured accurately, which is a well-known difficult problem in the portable type measurement of the low-frequency feeble current signal. In this paper, a new method with design principle and the simulation result by Saber to reduce the effect of the gap in the transducer is introduced. The academic lower limiting frequency of the transducer is nearly zero and the upper limiting frequency is infinity. The test of the current transducer shows that the low limiting frequency of the transducer is improved, which can be use in most systems to reduce the effect of gap with broad pass-bandwidth, high linearity and high sensitivity.

Xanya Sofra Weiss

Xanya Sofra Weiss

A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer. Xanya Sofra Weiss

Filed under: Xanya Sofra Weiss — Tags: — Dr. Xanya @ 6:59 pm

Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Manson JE, Li J ,Harris TG, Rohan TE, Xue X, Ho GY, Einstein MH, Kaplan RC, Burk RD,Wylie-Rosett J, Pollak MN, Anderson G, Howard BV, Strickler HD;  2008

Obesity is a major risk factor for endometrial cancer, a relationship thought to be largely explained by the prevalence of high estrogen levels in obese women. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed whether insulin and/or insulin-like growth factor-I (IGF-I), a related hormone, are associated with endometrial cancer while accounting for estrogen levels. We therefore conducted a case-cohort study of incident endometrial cancer in the Women’s Health Initiative Observational Study, a prospective cohort of 93,676 postmenopausal women. The study involved all 250 incident cases and a random subcohort of 465 subjects for comparison. Insulin, total IGF-I, free IGF-I, IGF-binding protein-3, glucose, and estradiol levels were measured in fasting baseline serum specimens. Cox models were used to estimate associations with endometrial cancer, particularly endometrioid adenocarcinomas, the main histologic type (n = 205). Our data showed that insulin levels were positively associated with endometrioid adenocarcinoma [hazard ratio contrasting highest versus lowest quartile (HR(q4-q1)), 2.33; 95% confidence interval (95% CI), 1.13-4.82] among women not using hormone therapy after adjustment for age and estradiol. Free IGF-I was inversely associated with endometrioid adenocarcinoma (HR(q4-q1), 0.53; 95% CI, 0.31-0.90) after adjustment for age, hormone therapy use, and estradiol. Both of these associations were stronger among overweight/obese women, especially the association between insulin and endometrioid adenocarcinoma (HR(q4-q1), 4.30; 95% CI, 1.62-11.43). These data indicate that hyperinsulinemia may represent a risk factor for endometrioid adenocarcinoma that is independent of estradiol. Free IGF-I levels were inversely associated with endometrioid adenocarcinoma, consistent with prior cross-sectional data.

Xanya Sofra Weiss

Xanya Sofra Weiss

January 24, 2011

Effect of microcurrent electrical tissue stimulation on equine tenocytes in culture. Xanya Sofra Weiss

Filed under: Xanya Sofra Weiss — Tags: — Dr. Xanya @ 10:06 pm

Yi-lo Lin, DVM, MSc Hugo Moolenaar, PhD P. René van Weeren, DVM, PhD Chris H. A. van de Lest, PhD; 2006

Objective—To determine effects of microcurrent electrical tissue stimulation (METS) on equine tenocytes cultured from the superficial digital flexor tendon (SDFT).

Sample Population—SDFTs were collected from 20 horses at slaughter.

Procedure—Tenocytes were isolated following outgrowth from explants and grown in 48-well plates. Four methods of delivering current to the tenocytes with a METS device were tested. Once the optimal method was selected, current consisting of 0 (negative control), 0.05, 0.1, 0.5, 1.0, or 1.5 mA was applied to cells (8 wells/current intensity) once daily for 8 minutes. Cells were treated for 1, 2, or 3 days. Cell proliferation, DNA content, protein content, and apoptosis rate were determined.

Results—Application of microcurrent of moderate intensity increased cell proliferation and DNA content, with greater increases with multiple versus single application. Application of microcurrent of moderate intensity once or twice increased protein content, but application 3 times decreased protein content. Application of current a single time did not significantly alter apoptosis rate; however, application twice or 3 times resulted in significant increases in apoptosis rate, and there were significant linear (second order) correlations between current intensity and apoptosis rate when current was applied twice or 3 times.

Conclusions and Clinical Relevance—Results of the present study indicate that microcurrent affects the behavior of equine tenocytes in culture, but that effects may be negative or positive depending on current intensity and number of applications. Therefore, results are far from conclusive with respect to the suitability of using METS to promote tendon healing in horses.

Xanya Sofra Weiss

Xanya Sofra Weiss

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